The Tubulin Fraternity: Alpha to Eta

Curr Opin Cell Biol. 2001 Feb;13(1):49-54. doi: 10.1016/s0955-0674(00)00173-3.


Microtubules perform essential and diverse functions in eukaryotic cells. They are required for spindles during mitosis and meiosis, for axonal transport, for organelle positioning, and for cilia and flagella. gamma-tubulin is necessary to initiate the assembly of alpha-beta tubulin heterodimers into microtubule polymers. Recent genetic analyses and database searches have added four new members of the tubulin superfamily, which now includes alpha-, beta-, gamma-, delta-, epsilon-, zeta-, and eta-tubulin.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Humans
  • Multigene Family
  • Protein Isoforms / chemistry
  • Tubulin / chemistry*


  • Protein Isoforms
  • Tubulin