Asymmetric cell division: fly neuroblast meets worm zygote

Curr Opin Cell Biol. 2001 Feb;13(1):68-75. doi: 10.1016/s0955-0674(00)00176-9.

Abstract

Both Drosophila neuroblasts and Caenorhabditis elegans zygotes use a conserved protein complex to establish cell polarity and regulate spindle orientation. Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / embryology*
  • Cell Division / physiology
  • Cell Polarity / physiology
  • Drosophila / cytology
  • Drosophila / embryology*
  • Humans
  • Nervous System / cytology
  • Nervous System / embryology*
  • Neurons / cytology*
  • Neurons / physiology
  • Zygote / cytology*
  • Zygote / growth & development