Cell-cycle-dependent translational control

Curr Opin Genet Dev. 2001 Feb;11(1):13-8. doi: 10.1016/s0959-437x(00)00150-7.


Control of translation in eukaryotes occurs mainly at the initiation step. Translation rates in mammals are robust in the G1 phase of the cell cycle but are low during mitosis. These changes correlate with the activity of several canonical translation initiation factors, which is modulated during the cell cycle to regulate translation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Interphase*
  • Mitosis
  • Picornaviridae / genetics
  • Picornaviridae / metabolism
  • Protein Biosynthesis*
  • RNA Caps
  • Signal Transduction
  • Yeasts / genetics
  • Yeasts / metabolism


  • RNA Caps