Cytoskeletal changes in cell transformation and tumorigenesis

Curr Opin Genet Dev. 2001 Feb;11(1):41-7. doi: 10.1016/s0959-437x(00)00154-4.


Research during the past couple of years has provided important new information as to how the actin cytoskeleton contributes to growth control in both normal and transformed cells. The cytoskeleton can no longer be viewed as simply a structural framework playing a role in cell shape and motile events such as cell movement, intracellular transport, contractile-ring formation and chromosome movement. More recent experiments show that the cytoskeleton plays a critical role in the regulation of various cellular processes linked to transformation including proliferation, contact inhibition, anchorage-independent cell growth, and apoptosis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / physiology
  • Animals
  • Apoptosis
  • Cell Adhesion
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Neoplastic / pathology
  • Cytoskeleton / metabolism*
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Models, Biological
  • Signal Transduction


  • Actins
  • GTP Phosphohydrolases