Molecular markers of tumor initiation and progression

Curr Opin Genet Dev. 2001 Feb;11(1):60-3. doi: 10.1016/s0959-437x(00)00157-x.


Of the hundreds of genes and proteins reported to be altered in human cancers, only a few are sufficiently central to warrant translation into diagnostic or therapeutic tools. Three recent developments have the potential to alter radically the discovery of molecular markers: the compendium of human genes; the advent of technologies that provide the means to identify simultaneously several known and unknown genes and proteins; and an appreciation of the critical processes involved in tumor initiation and progression.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / metabolism
  • DNA, Neoplasm / genetics*
  • DNA, Neoplasm / metabolism
  • Genes, Tumor Suppressor
  • Genes, cdc
  • Genetic Markers
  • Humans
  • Loss of Heterozygosity
  • Oligonucleotide Array Sequence Analysis*
  • Oncogenes


  • DNA, Neoplasm
  • Genetic Markers