Mitotic checkpoints: from yeast to cancer

K Wassmann; R Benezra

doi:10.1016/s0959-437x(00)00161-1

Mitotic checkpoints: from yeast to cancer

Curr Opin Genet Dev. 2001 Feb;11(1):83-90. doi: 10.1016/s0959-437x(00)00161-1.

Authors

K Wassmann¹, R Benezra

Affiliation

¹ Cell Biology Program, Memorial Sloan-Kettering Cancer Center and the Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, Box 241, 1275 York Avenue, New York, New York 10021, USA.

PMID: 11163156
DOI: 10.1016/s0959-437x(00)00161-1

Abstract

Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Adenomatous Polyposis Coli Protein
Anaphase / genetics
Animals
Cytoskeletal Proteins / metabolism
Genes, cdc*
Humans
Kinetochores / metabolism
Metaphase / genetics
Mitosis / genetics*
Neoplasms / pathology*
Spindle Apparatus / metabolism
Yeasts / cytology*

Substances

Adenomatous Polyposis Coli Protein
Cytoskeletal Proteins

Grant support

GM 54601/GM/NIGMS NIH HHS/United States