Mitotic checkpoints: from yeast to cancer

Curr Opin Genet Dev. 2001 Feb;11(1):83-90. doi: 10.1016/s0959-437x(00)00161-1.

Abstract

Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenomatous Polyposis Coli Protein
  • Anaphase / genetics
  • Animals
  • Cytoskeletal Proteins / metabolism
  • Genes, cdc*
  • Humans
  • Kinetochores / metabolism
  • Metaphase / genetics
  • Mitosis / genetics*
  • Neoplasms / pathology*
  • Spindle Apparatus / metabolism
  • Yeasts / cytology*

Substances

  • Adenomatous Polyposis Coli Protein
  • Cytoskeletal Proteins