Coordinating cell proliferation and differentiation

Curr Opin Genet Dev. 2001 Feb;11(1):91-7. doi: 10.1016/s0959-437x(00)00162-3.


Cell proliferation and differentiation are highly coordinated processes during development. Recent studies have revealed that this coordination may result from dual functions residing in the central regulators of proliferation, allowing them to also regulate differentiation. Studies have also shown that some terminally differentiated cells can be made to divide beyond their normal capacity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics*
  • Cell Differentiation / physiology
  • Cell Division / genetics
  • Cell Division / physiology
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclin-Dependent Kinases / metabolism*
  • Genes, cdc / physiology*
  • Humans


  • Cyclin-Dependent Kinases