Immune Response in Stat2 Knockout Mice

Immunity. 2000 Dec;13(6):795-804. doi: 10.1016/s1074-7613(00)00077-7.

Abstract

Type I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate either to form Stat1 homodimers or the transcription factor ISGF-3. Stat1 homodimers also transduce signals for IFN-gamma. To explore the unique properties of Stat2 and ISGF-3 in type I IFN signaling, its gene was targeted for deletion. Stat2 null mice exhibit a number of defects in immune response. This includes an increased susceptibility to viral infection and the loss of a type I IFN autocrine/ paracrine loop, which in turn regulates several aspects of immune response. Intriguingly, Stat2-deficient fibroblasts exhibit a more significant defect in their response to type I IFNs than macrophages, highlighting tissue-specific differences in the response to this family of ligands.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / immunology*
  • GTP Phosphohydrolases / genetics
  • Gene Deletion
  • Gene Expression
  • Gene Targeting
  • Interferon Regulatory Factor-1
  • Interferon-Stimulated Gene Factor 3
  • Interferon-Stimulated Gene Factor 3, gamma Subunit
  • Interferon-alpha / immunology
  • Interferon-gamma / immunology
  • Mice
  • Mice, Knockout
  • Phosphoproteins / genetics
  • Rhabdoviridae Infections / immunology
  • STAT2 Transcription Factor
  • Signal Transduction / immunology*
  • Trans-Activators / immunology*
  • Transcription Factors / genetics
  • Vesicular stomatitis Indiana virus / immunology

Substances

  • DNA-Binding Proteins
  • Interferon Regulatory Factor-1
  • Interferon-Stimulated Gene Factor 3
  • Interferon-Stimulated Gene Factor 3, gamma Subunit
  • Interferon-alpha
  • Irf1 protein, mouse
  • Isgf3g protein, mouse
  • Phosphoproteins
  • STAT2 Transcription Factor
  • Stat2 protein, mouse
  • Trans-Activators
  • Transcription Factors
  • Interferon-gamma
  • GTP Phosphohydrolases