Mechanism of Measles Virus-Induced Suppression of Inflammatory Immune Responses

Immunity. 2001 Jan;14(1):69-79. doi: 10.1016/s1074-7613(01)00090-5.

Abstract

Measles virus (MV) causes profound immunosuppression, resulting in high infant mortality. The mechanisms are poorly understood, largely due to the lack of a suitable animal model. Here, we report that particular MV proteins, in the absence of MV replication, could generate a systemic immunosuppression in mice through two pathways: (1) via MV-nucleoprotein and its receptor FcgammaR on dendritic cells; and (2) via virus envelope glycoproteins and the MV-hemagglutinin cellular receptor, CD46. The effects comprise reduced hypersensitivity responses associated with impaired function of dendritic cells, decreased production of IL-12, and the loss of antigen-specific T cell proliferation. These results introduce a novel model for testing the immunosuppressive potential of anti-measles vaccines and reveal a specific mechanism of MV-induced modulation of inflammatory reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Antigens, CD / genetics
  • Antigens, CD / immunology*
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / cytology
  • CD8-Positive T-Lymphocytes / immunology
  • Cell Division
  • Dendritic Cells / immunology
  • Dermatitis, Contact / immunology
  • Dinitrofluorobenzene / immunology
  • Disease Models, Animal
  • Hemagglutinins, Viral / immunology*
  • Hemocyanins / immunology
  • Hypersensitivity, Delayed / chemically induced
  • Hypersensitivity, Delayed / immunology
  • Immunosuppressive Agents / immunology*
  • Interleukin-12 / biosynthesis
  • Lymph Nodes / immunology
  • Measles virus / immunology*
  • Membrane Cofactor Protein
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nucleoproteins / immunology*
  • Receptors, IgG / immunology*
  • Ultraviolet Rays
  • Viral Fusion Proteins / immunology*
  • Viral Proteins / immunology*

Substances

  • Antigens, CD
  • Hemagglutinins, Viral
  • Immunosuppressive Agents
  • Mcp protein, mouse
  • Membrane Cofactor Protein
  • Membrane Glycoproteins
  • Nucleoproteins
  • Receptors, IgG
  • Viral Fusion Proteins
  • Viral Proteins
  • hemagglutinin protein G, measles virus
  • nucleoprotein, Measles virus
  • Interleukin-12
  • Hemocyanins
  • Dinitrofluorobenzene
  • keyhole-limpet hemocyanin