Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields

FEBS Lett. 2001 Jan 5;487(3):397-403. doi: 10.1016/s0014-5793(00)02376-0.


Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re-established the apoptotic response to ELF-MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF-MF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis
  • Ataxia Telangiectasia / genetics
  • Ataxia Telangiectasia / pathology
  • Cell Cycle
  • Cell Death*
  • Cell Line
  • Fanconi Anemia / genetics
  • Fanconi Anemia / pathology
  • Humans
  • Lymphocytes / cytology
  • Magnetics / adverse effects*
  • Microscopy, Electron
  • Mutation
  • Transfection