The Pathogenesis of Nontypable Haemophilus Influenzae Otitis Media

Vaccine. 2000 Dec 8;19 Suppl 1:S41-50. doi: 10.1016/s0264-410x(00)00277-2.

Abstract

Nontypable Haemophilus influenzae is a common cause of otitis media and initiates infection by colonizing the upper respiratory tract. In this article, I review our current understanding of the molecular determinants of H. influenzae colonization and discuss the relationship between colonization and otitis media.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adhesins, Bacterial / genetics
  • Adhesins, Bacterial / physiology
  • Adolescent
  • Adult
  • Antibodies, Bacterial / immunology
  • Antigenic Variation
  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / immunology
  • Bacterial Adhesion
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / physiology
  • Bacterial Typing Techniques
  • Carrier State / epidemiology
  • Carrier State / microbiology
  • Child
  • Child, Preschool
  • Cilia / microbiology
  • Fimbriae Proteins*
  • Fimbriae, Bacterial / physiology
  • Haemophilus Infections / epidemiology
  • Haemophilus Infections / microbiology*
  • Haemophilus influenzae / classification
  • Haemophilus influenzae / genetics
  • Haemophilus influenzae / immunology
  • Haemophilus influenzae / pathogenicity*
  • Humans
  • Immunoglobulin A / immunology
  • Infant
  • Lipopolysaccharides / metabolism
  • Mucus / microbiology
  • Operon / genetics
  • Otitis Media / microbiology*
  • Point Mutation
  • Serine Endopeptidases / physiology
  • Species Specificity

Substances

  • Adhesins, Bacterial
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • HMW1 protein, bacteria
  • HMW2 protein, bacteria
  • Hap protein, Hemophilus influenzae
  • Hia adhesin
  • HifA protein, Haemophilus influenzae
  • Immunoglobulin A
  • Lipopolysaccharides
  • Fimbriae Proteins
  • Serine Endopeptidases
  • IgA-specific serine endopeptidase