Quality Control for Nucleic Acid Tests: Common Ground and Special Issues

J Clin Virol. 2001 Jan;20(1-2):15-21. doi: 10.1016/s1386-6532(00)00150-5.

Abstract

Traditional clinical laboratory quality control practices are being applied to new technologies for the detection and quantitation of nucleic acids in clinical samples, often with limited knowledge of the probability for clinically significant error detection or for false run rejection of such practices. This article reviews traditional quality control practices, discusses the possibilities for a more rational approach to quality control for nucleic acid tests and suggests some steps that can lead to quality improvement for these tests.

Publication types

  • Review

MeSH terms

  • Clinical Laboratory Techniques / standards*
  • HIV Infections / diagnosis
  • Hepatitis / diagnosis
  • Humans
  • Nucleic Acids / analysis*
  • Quality Control
  • RNA, Viral / analysis
  • Sensitivity and Specificity
  • Viral Load

Substances

  • Nucleic Acids
  • RNA, Viral