Genomic organization and alternative transcripts of the human PQBP-1 gene

Gene. 2000 Dec 23;259(1-2):69-73. doi: 10.1016/s0378-1119(00)00437-6.


PQBP-1 has been identified as a protein that binds to huntingtin, androgen receptor and transcription factor Brain-2 through their homopolymeric glutamine repeats. We here report the genomic organization of the human PQBP-1 gene and its multiple alternative transcripts. The coding region of PQBP-1 comprises six exons and five introns, and four types of alternative transcript, designated PQBP-1a to PQBP-1d, were found in addition to the PQBP-1 transcript reported originally. All of the PQBP-1 transcripts retain the WW domain in the N-terminal region, a potent transactivator domain. On the other hand, there is a wide variation in their C-terminal regions. Importantly, PQBP-1a and PQBP-1d lack the domain responsible for the interaction with homopolymeric glutamine repeats and a nuclear localization signal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing*
  • Amino Acid Sequence
  • Carrier Proteins / genetics*
  • DNA / chemistry
  • DNA / genetics
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • DNA-Binding Proteins
  • Exons
  • Genes / genetics*
  • Humans
  • Introns
  • Molecular Sequence Data
  • Nuclear Proteins / genetics*
  • Sequence Analysis, DNA
  • Transcription, Genetic


  • Carrier Proteins
  • DNA, Complementary
  • DNA-Binding Proteins
  • Nuclear Proteins
  • PQBP1 protein, human
  • DNA

Associated data

  • GENBANK/AB041832
  • GENBANK/AB041833
  • GENBANK/AB042834
  • GENBANK/AB042835
  • GENBANK/AB042836