Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers

Cancer Lett. 2001 Jan;162 Suppl:S33-S37. doi: 10.1016/s0304-3835(00)00650-9.

Abstract

Several types of virus were found to have a strong association with different types of cancers. Thus, a selective antiviral compound without toxicity upon long-term usage will be useful not only for the treatment of viral diseases but also for the prevention or the delayed onset of those cancers, which have a strong association with viruses. L(-)Nucleoside analogs were discovered recently in my laboratory as an important class of antiviral and anticancer chemical entities. L(-)SddC (3TC, Lamivudine), FTC, Fd4C, and L(-)FMAU are potent anti-HBV compounds with different pharmacological profiles. These compounds may be useful in the prevention or delayed onset of hepatocellular carcinoma associated with HBV. L(-)I-OddU is the most potent anti-Epstein-Barr Virus (EBV) compound without cytotoxicity and animal toxicity upon long-term dosing which gives the pharmacological levels of the drug in plasma. This compound may have the potential to prevent B-cell lymphoma associated with patients undergoing organ transplants in addition to its potential use for the treatment of EBV infection.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Arabinofuranosyluracil / analogs & derivatives
  • Arabinofuranosyluracil / pharmacology
  • Dioxolanes / pharmacology
  • Hepatitis B virus / drug effects
  • Herpesvirus 4, Human / drug effects
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / etiology
  • Nucleosides / chemistry
  • Nucleosides / pharmacology*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Uracil / analogs & derivatives
  • Uracil / pharmacology
  • Virus Diseases / complications
  • Virus Diseases / prevention & control*
  • Virus Diseases / virology
  • Zalcitabine / analogs & derivatives*
  • Zalcitabine / pharmacology

Substances

  • 5-iododioxolane uracil
  • Antiviral Agents
  • Dioxolanes
  • Nucleosides
  • Arabinofuranosyluracil
  • Uracil
  • Zalcitabine
  • clevudine
  • dexelvucitabine