Factors determining peripheral vein tolerance to amino acid infusions

Arch Surg. 1979 Aug;114(8):897-900. doi: 10.1001/archsurg.1979.01370320029005.


The tolerance of peripheral veins to intravenous infusions was evaluated. Of 83 infusions studied, 67 contained amino acids. Phlebitis occurred more commonly with the use of solutions that contained the amino acids. The important factors in the production of phlebitis by amino acid solutions were osmolarity, and the amount of potassium infused per day. Phlebitis was universal when osmolarity exceeded 600 mOsm. Other factors that promoted phlebitis were the presence of antibiotics and the size of the vein.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acids / adverse effects*
  • Humans
  • Infusions, Parenteral / adverse effects*
  • Osmolar Concentration
  • Parenteral Nutrition / adverse effects
  • Phlebitis / chemically induced*
  • Potassium / adverse effects


  • Amino Acids
  • Potassium