Time sequence and types of memory deficits after experimental status epilepticus

Epilepsy Res. 2001 Feb;43(2):97-101. doi: 10.1016/s0920-1211(00)00187-x.

Abstract

P35 rats subjected to kainate induced status epilepticus (SE) subsequently underwent four consecutive series of the Morris Water Maze. They demonstrated, compared with controls, an early (P46-49), and subsequent (P60-63) disturbance in acquisition, but not in long term retention, of spatial memory. They eventually achieved performance levels similar to those of controls (P74-77, P91-94). These data support the hypothesis that acquisition, but not long term retention, of spatial material is impaired in this model of temporal lobe epilepsy (TLE), probably due to the hippocampal injury that occurs after SE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Excitatory Amino Acid Agonists
  • Kainic Acid
  • Male
  • Maze Learning / physiology
  • Memory Disorders / etiology*
  • Memory Disorders / psychology*
  • Rats
  • Rats, Sprague-Dawley
  • Reaction Time / physiology
  • Status Epilepticus / chemically induced
  • Status Epilepticus / psychology*
  • Swimming

Substances

  • Excitatory Amino Acid Agonists
  • Kainic Acid