CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination

J Neuroimmunol. 2001 Feb 15;113(2):220-30. doi: 10.1016/s0165-5728(00)00450-1.

Abstract

Expression of CD1 by microglia, macrophages and T cells was investigated ex vivo. In the healthy central nervous system (CNS), resident microglia, macrophages and T cells express levels of CD1 significantly lower than that expressed by splenic macrophages and T cells. During experimental autoimmune encephalomyelitis (EAE), CD1 expression by microglia and the number of CD1+ microglia increase. Macrophages and T cells strongly upregulate CD1 expression in the CNS, but not in the spleen. Whereas the function of CD1 expressed by T cells remains unclear, the expression by microglia and macrophages provides the CNS with a (glyco)lipidic-presenting molecule in an inflammatory and demyelinating environment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • Antigens, CD1 / metabolism*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / metabolism
  • Cell Count
  • Central Nervous System / metabolism*
  • Demyelinating Diseases / metabolism*
  • Encephalomyelitis, Autoimmune, Experimental / metabolism*
  • Encephalomyelitis, Autoimmune, Experimental / pathology
  • Integrin alpha4
  • Macrophages / metabolism*
  • Mice
  • Mice, Inbred Strains
  • Microglia / metabolism*
  • Microglia / pathology
  • Spleen / metabolism
  • Spleen / pathology
  • T-Lymphocytes / metabolism*
  • T-Lymphocytes / physiology
  • Up-Regulation

Substances

  • Antigens, CD
  • Antigens, CD1
  • Integrin alpha4