The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites

Mech Dev. 2001 Feb;100(2):317-21. doi: 10.1016/s0925-4773(00)00538-4.


Several vertebrate genes of the Hairy/Enhancer-of-split (HES) family are involved in paraxial mesoderm segmentation and intersomitic boundary establishment/maintenance. Here, we show that the zebrafish hairy-related gene, her6, highly homologous to the mammalian and chicken HES-1 genes, is expressed in the posterior part of each segmented somite and in stripes in the anterior presomitic mesoderm (PSM), and also in a dynamic, segmentally restricted pattern during hindbrain segmentation, with all rhombomeres expressing her6 at different time points and at different levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Basic Helix-Loop-Helix Transcription Factors
  • Brain / embryology*
  • Chickens
  • Cloning, Molecular
  • DNA, Complementary / metabolism
  • Embryo, Nonmammalian
  • Humans
  • Mesoderm / metabolism
  • Mice
  • Molecular Sequence Data
  • Rats
  • Repressor Proteins / biosynthesis*
  • Repressor Proteins / genetics*
  • Rhombencephalon / metabolism
  • Sequence Homology, Amino Acid
  • Somites / metabolism*
  • Time Factors
  • Transcription Factors / biosynthesis*
  • Transcription Factors / genetics*
  • Xenopus
  • Zebrafish
  • Zebrafish Proteins*


  • Basic Helix-Loop-Helix Transcription Factors
  • DNA, Complementary
  • Her6 protein, zebrafish
  • Repressor Proteins
  • Transcription Factors
  • Zebrafish Proteins