Glutamate receptor channel signatures

Trends Pharmacol Sci. 2001 Jan;22(1):7-10. doi: 10.1016/s0165-6147(00)01588-1.


Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct channel pore signature for each receptor subtype and for most of them, related members were found in C. elegans and Drosophila.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans / genetics
  • Drosophila melanogaster / genetics
  • Ion Channel Gating
  • Ion Channels / chemistry
  • Ion Channels / genetics*
  • Molecular Sequence Data
  • Receptors, Glutamate / chemistry
  • Receptors, Glutamate / classification
  • Receptors, Glutamate / genetics*
  • Sequence Homology, Amino Acid


  • Ion Channels
  • Receptors, Glutamate