Involvement of Na+ channels in pain pathways

Trends Pharmacol Sci. 2001 Jan;22(1):27-31. doi: 10.1016/s0165-6147(00)01585-6.


Voltage-dependent Na+ channels in sensory nerves contribute to the control of membrane excitability and underlie action potential generation. Na+ channel subtypes exhibit a neurone-specific and developmentally regulated pattern of expression, and changes in both channel expression and function are caused by disease. Recent evidence implicates specific roles for Na+ channel subtypes Na(v)1.3 and Na(v)1.8 in pain states that are associated with nerve injury and inflammation, respectively. Insight into the role of Na(v)1.8 in pain pathways has been gained by the generation of a null mutant. Although drugs discriminate poorly between subtypes, the molecular diversity of channels and subtype-specific modulation might provide opportunities to target pain pathways selectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Anesthetics, Inhalation / pharmacology
  • Anesthetics, Local / pharmacology
  • Animals
  • Halothane / pharmacology
  • Humans
  • Neurons, Afferent / physiology
  • Pain / drug therapy
  • Pain / physiopathology*
  • Sodium Channel Blockers
  • Sodium Channels / physiology*


  • Anesthetics, Inhalation
  • Anesthetics, Local
  • Sodium Channel Blockers
  • Sodium Channels
  • Halothane