Abstract
Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show that the passengers inner centromere protein (INCENP) and aurora-B kinase are in a macromolecular complex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Aurora Kinase B
-
Aurora Kinases
-
Cell Death / physiology
-
Chromosomal Proteins, Non-Histone / metabolism*
-
Inhibitor of Apoptosis Proteins
-
Microtubule-Associated Proteins*
-
Microtubules / metabolism*
-
Mitosis / physiology*
-
Neoplasm Proteins
-
Protein Serine-Threonine Kinases / metabolism*
-
Proteins / metabolism*
-
Survivin
Substances
-
BIRC5 protein, human
-
Chromosomal Proteins, Non-Histone
-
Inhibitor of Apoptosis Proteins
-
Microtubule-Associated Proteins
-
Neoplasm Proteins
-
Proteins
-
Survivin
-
AURKB protein, human
-
Aurora Kinase B
-
Aurora Kinases
-
Protein Serine-Threonine Kinases