Chromosomal Passengers and the (Aurora) ABCs of Mitosis

Trends Cell Biol. 2001 Feb;11(2):49-54. doi: 10.1016/s0962-8924(00)01880-8.

Abstract

Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show that the passengers inner centromere protein (INCENP) and aurora-B kinase are in a macromolecular complex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aurora Kinase B
  • Aurora Kinases
  • Cell Death / physiology
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins*
  • Microtubules / metabolism*
  • Mitosis / physiology*
  • Neoplasm Proteins
  • Protein-Serine-Threonine Kinases / metabolism*
  • Proteins / metabolism*
  • Survivin

Substances

  • BIRC5 protein, human
  • Chromosomal Proteins, Non-Histone
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins
  • Neoplasm Proteins
  • Proteins
  • Survivin
  • AURKB protein, human
  • Aurora Kinase B
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases