Molecular mechanisms of blood vessel growth

Cardiovasc Res. 2001 Feb 16;49(3):507-21. doi: 10.1016/s0008-6363(00)00281-9.


The basic molecular mechanisms governing how endothelial cells, periendothelial cells and matrix molecules interact with each other and with numerous growth factors and receptors, to form blood vessels have been presented. The many insights gained from this basic knowledge are being extended to further understand pathological angiogenesis associated with disorders such as arterial stenosis, myocardial ischemia, atherosclerosis, allograft transplant stenosis. wound healing and tissue repair. As a result, novel angiogenic and anti-angiogenic molecules are rapid-ly entering the clinic, with the promise of relief from a host of medical disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteries
  • Blood Vessels / embryology*
  • Cell Differentiation
  • Cell Division
  • Endothelium, Vascular / embryology
  • Gene Expression
  • Growth Substances / genetics*
  • Growth Substances / physiology
  • Morphogenesis / physiology
  • Oxygen / metabolism
  • Signal Transduction / physiology*
  • Stress, Mechanical
  • Veins
  • Yolk Sac / blood supply


  • Growth Substances
  • Oxygen