RUN domains: a new family of domains involved in Ras-like GTPase signaling

Trends Biochem Sci. 2001 Feb;26(2):79-83. doi: 10.1016/s0968-0004(00)01730-8.


RUN domains are present in several proteins that are linked particularly to the functions of GTPases in the Rap and Rab families. They could hence play an important role in multiple Ras-like GTPase signaling pathways.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTP Phosphohydrolases / metabolism*
  • Genome
  • Humans
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid
  • Signal Transduction*
  • ras Proteins / chemistry*


  • GTP Phosphohydrolases
  • ras Proteins