PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases

Trends Biochem Sci. 2001 Feb;26(2):85-7. doi: 10.1016/s0968-0004(00)01729-1.


A new protein domain was found in several proteins involved in apoptosis, inflammation, cancer and immune responses. Its location within these proteins and predicted fold suggests that it functions as a protein-protein interaction domain, possibly uniting different signaling pathways.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis*
  • Autoimmune Diseases / metabolism*
  • Cytoskeletal Proteins
  • Databases, Factual
  • Humans
  • Inflammation / metabolism
  • Molecular Sequence Data
  • Neoplasms / metabolism*
  • Protein Binding
  • Protein Folding
  • Protein Structure, Tertiary
  • Proteins / chemistry
  • Pyrin
  • Sequence Homology, Amino Acid
  • Signal Transduction


  • Cytoskeletal Proteins
  • Proteins
  • Pyrin