Selenium (Se) is a dietary trace mineral in which there has recently been a surge of interest, in both the popular and the scientific press, because of its demonstrated anti-carcinogenic and anti-inflammatory properties in humans. In this short review, I will explain why Se is an important component of cellular anti-oxidant defences and review its protective effects against UV radiation-induced damage to skin cells. Although little is known about whether selenium can protect human skin from UV-induced damage, clinical studies are underway and the anti-oxidant may offer considerable benefits.