Being edentulous is a handicap, and the main objective of implant placement is to provide support of fixed prostheses or to stabilize complete dentures in the edentulous jaw. Clinical experience and clinical studies have demonstrated the broad application of non-submerged ITI implants in prosthetic therapy in standard sites and in situations of advanced atrophy or substantial loss of tissue. The ITI implant was developed for universal use in partially and completely edentulous patients and for replacement of single missing teeth. The abutment system offers the choice of both removable and fixed prostheses with identical secondary parts. The present article describes the use of ITI implants for prosthodontic rehabilitation in the completely edentulous jaw. Indications and various types of fixed or removable prostheses, alternatives and variations of design are discussed. Prosthetic design is dependent on the number and location of implants, and conversely, the number of implants that can be placed will determine the choice of prosthesis. Treatment planning in general and with respect to individual anatomic-morphologic conditions is described for the upper and lower jaw. Details of clinical procedures with ITI implants related to the specific design of prostheses are presented. Biomechanical aspects of fixation and stabilization of prostheses and aspects of occlusion to be built up complete the overview.