Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint

J Cutan Pathol. 2001 Feb;28(2):57-64. doi: 10.1034/j.1600-0560.2001.280201.x.

Abstract

From an oncological and immunological perspective, the T-cell-mediated induction of psoriatic plaques should be prone to malignant transformation as the phenotype of psoriatic plaques includes: chronic inflammation, epidermal hyperplasia, prolonged survival and elevated telomerase levels in lesional keratinocytes, as well as angiogenesis, exposure to carcinogens and immunosuppressants. However, conversion of a psoriatic plaque to squamous cell carcinoma is exceedingly rare. This paper explores the possible molecular mechanism for the tumor suppressor pathway in psoriatic lesions, with an emphasis on a putative senescence-switch involving p16.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / pathology
  • Cell Transformation, Neoplastic
  • Genes, Tumor Suppressor*
  • Humans
  • Keratinocytes / pathology
  • Models, Biological
  • Precancerous Conditions
  • Psoriasis* / complications
  • Psoriasis* / genetics
  • Psoriasis* / immunology
  • Psoriasis* / pathology
  • Skin Neoplasms / etiology
  • Skin Neoplasms / pathology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology*