HLA-DRB1*03, DRB1*11 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis

Tissue Antigens. 2001 Jan;57(1):87-90. doi: 10.1034/j.1399-0039.2001.057001087.x.


Determination of DRB1 and DRB3 specificities in sarcoidosis patients identified that the presence of DRB1*03 and the absence of DRB1*11 and/or DRB1*12 favors a course of disease that is associated positively with Löfgren's syndrome (DRB1*03) and negatively with stage I disease (DRB1*11 and/or 12). In common with normal controls, DRB1*03 was associated with DRB3*0101 and DRB1*11/12 with DRB3*0201/2. An analysis of DRB1 and DRB3 associations in variants of sarcoidosis revealed that DRB1*03 and DRB3*0101 were associated with Löfgren's syndrome in a combined association fashion. Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Genetic Variation / genetics
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • HLA-DRB3 Chains
  • Humans
  • Male
  • Middle Aged
  • Sarcoidosis / genetics*


  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*12:12 antigen
  • HLA-DRB3 Chains