Activation of STAT proteins and growth control

Bioessays. 2001 Feb;23(2):161-9. doi: 10.1002/1521-1878(200102)23:2<161::AID-BIES1023>3.0.CO;2-0.

Abstract

This review will discuss how STAT (Signal Transducers and Activators of Transcription) proteins, a group of transcription factors that transmit signals from the extracellular surface of cells to the nucleus, are involved in growth control. I will discuss the anatomy of a STAT protein, how it works as a transcription factor, the molecules that regulate its "activity", the phenotypes of mice that lack individual STAT proteins and their involvement in growth, differentiation, apoptosis, and transformation. Finally, a number of examples will be presented of how dysregulated STAT signaling may be involved in the pathogenesis of cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cell Division
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • DNA-Binding Proteins / physiology*
  • Humans
  • Mice
  • Milk Proteins*
  • Protein Structure, Tertiary
  • STAT1 Transcription Factor
  • STAT2 Transcription Factor
  • STAT3 Transcription Factor
  • STAT4 Transcription Factor
  • STAT5 Transcription Factor
  • STAT6 Transcription Factor
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism
  • Trans-Activators / physiology*
  • Transcriptional Activation

Substances

  • DNA-Binding Proteins
  • Milk Proteins
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • STAT2 Transcription Factor
  • STAT2 protein, human
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • STAT4 Transcription Factor
  • STAT4 protein, human
  • STAT5 Transcription Factor
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • Stat1 protein, mouse
  • Stat3 protein, mouse
  • Stat4 protein, mouse
  • Stat6 protein, mouse
  • Trans-Activators