Src family kinase function during early Xenopus development

Dev Dyn. 2001 Feb;220(2):163-8. doi: 10.1002/1097-0177(2000)9999:9999<1::AID-DVDY1098>3.0.CO;2-5.


The Src family kinase Laloo functions downstream of the fibroblast growth factor (FGF) receptor, as a component of a signaling pathway required for mesoderm formation. In this study, we first show that Laloo expression can mimic FGF function in a distinct context, suggesting that the Src-related kinases are general transducers of FGF signaling during development. We then characterize the role of the SH-PTP2 phosphatase, and of bone morphogenetic protein (BMP)-pathway signaling, in mesoderm induction by Laloo. Finally, we demonstrate that the mesoderm-inducing activity of the Src family kinases is not limited to Laloo, indicating a degree of functional overlap between members of this gene family during early vertebrate development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / physiology
  • Embryo, Nonmammalian / physiology
  • Gene Expression Regulation, Developmental
  • Mesoderm / physiology*
  • Receptors, Fibroblast Growth Factor / genetics
  • Receptors, Fibroblast Growth Factor / physiology*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Xenopus / embryology*
  • Xenopus Proteins*
  • src Homology Domains
  • src-Family Kinases / metabolism*


  • Bone Morphogenetic Proteins
  • HCK protein, Xenopus
  • Receptors, Fibroblast Growth Factor
  • Xenopus Proteins
  • src-Family Kinases