Circumdatin G, a New Alkaloid From the Fungus Aspergillus Ochraceus

J Nat Prod. 2001 Jan;64(1):125-6. doi: 10.1021/np000381u.

Abstract

The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Aspergillus ochraceus / chemistry*
  • Fermentation
  • Hepacivirus / drug effects
  • Hepacivirus / enzymology
  • Isocoumarins
  • Magnetic Resonance Spectroscopy
  • Ochratoxins / chemistry
  • Ochratoxins / isolation & purification*
  • Ochratoxins / pharmacology
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / isolation & purification
  • Protease Inhibitors / pharmacology
  • Virus Replication / drug effects

Substances

  • Alkaloids
  • Antiviral Agents
  • Isocoumarins
  • Ochratoxins
  • Protease Inhibitors
  • circumdatin F
  • circumdatin G
  • ochracin