An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds

Biochem J. 2001 Feb 1;353(Pt 3):441-4. doi: 10.1042/0264-6021:3530441.


The cDNA of an uncoupling protein (UCP) homologue was obtained by screening a chicken skeletal-muscle library. The predicted 307-amino-acid sequence of avian UCP (avUCP) is 55, 70, 70 and 46% identical with mammalian UCP1, UCP2 and UCP3 and plant UCP respectively. avUCP mRNA expression is restricted to skeletal muscle and its abundance was increased 1.3-fold in a chicken line showing diet-induced thermogenesis, and 3.6- and 2.6-fold in cold-acclimated and glucagon-treated ducklings developing muscle non-shivering thermogenesis respectively. The present data support the implication of avUCP in avian energy expenditure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Avian Proteins*
  • Base Sequence
  • Blotting, Northern
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Chickens
  • DNA Primers
  • DNA, Complementary
  • Mitochondrial Proteins*
  • Mitochondrial Uncoupling Proteins
  • Molecular Sequence Data
  • Muscle, Skeletal / physiology*
  • RNA, Messenger / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Thermogenesis / physiology*


  • Avian Proteins
  • Carrier Proteins
  • DNA Primers
  • DNA, Complementary
  • Mitochondrial Proteins
  • Mitochondrial Uncoupling Proteins
  • RNA, Messenger
  • mitochondrial uncoupling protein, chicken

Associated data

  • GENBANK/AF287144