Gene targeting in hemostasis. tissue factor

Front Biosci. 2001 Feb 1;6:D208-15. doi: 10.2741/mackman.

Abstract

Tissue factor (TF) is the primary cellular initiator of blood coagulation. At sites of vascular injury, formation of a TF:FVIIa complex leads to the generation of FXa, thrombin and the deposition of fibrin to limit hemorrhage. In contrast to its beneficial role in hemostasis, TF initiates life-threatening intravascular thrombosis in sepsis, atherosclerosis and cancer. More recently, TF has been proposed to play a role in other biological processes, including tumor-associated angiogenesis, metastasis and inflammation. Indeed, gene targeting of TF resulted in embryonic lethality, which appeared to be due to a defect in the yolk sac vasculature.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Coagulation / physiology
  • Blood Coagulation Disorders / embryology
  • Blood Coagulation Disorders / genetics
  • Gene Silencing
  • Gene Targeting
  • Hemostasis / genetics*
  • Humans
  • Mice
  • Neoplasm Metastasis / physiopathology
  • Neovascularization, Physiologic / physiology
  • Signal Transduction / physiology
  • Thrombin / metabolism
  • Thromboplastin / chemistry
  • Thromboplastin / deficiency
  • Thromboplastin / genetics*
  • Thromboplastin / metabolism
  • Yolk Sac / metabolism

Substances

  • Thromboplastin
  • Thrombin