Atypical MELAS syndrome associated with a new mitochondrial tRNA glutamine point mutation

Neurology. 2001 Feb 13;56(3):405-7. doi: 10.1212/wnl.56.3.405.


The authors studied a 47-year-old patient who presented with an association of deafness, acute cerebral stroke-like episode, leukoencephalopathy, and extensive basal ganglia calcifications. Late onset and neuroradiologic findings were atypical for MELAS syndrome (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike episodes). A heteroplasmic G to A transition at nucleotide 4332 in the tRNA glutamine gene was identified in the patient's muscle mitochondrial DNA. The pathogenicity of the mutation was shown in single muscle fibers by the correlation between high mutation load and cytochrome c oxidase defect.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Mitochondrial / genetics*
  • Glutamine / genetics*
  • Humans
  • MELAS Syndrome / diagnostic imaging
  • MELAS Syndrome / genetics*
  • MELAS Syndrome / pathology
  • Male
  • Middle Aged
  • Muscles / pathology
  • Point Mutation / genetics*
  • RNA, Transfer / genetics*
  • Tomography, X-Ray Computed


  • DNA, Mitochondrial
  • Glutamine
  • RNA, Transfer