The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression

FEBS Lett. 2001 Feb 9;490(1-2):11-4. doi: 10.1016/s0014-5793(01)02126-3.


The activity of transport system A for neutral amino acids is adaptively stimulated upon amino acid starvation. In cultured human fibroblasts this treatment causes an increase in the expression of the ATA2 system A transporter gene. ATA2 mRNA increase and transport stimulation are suppressed by system A substrates, but they are unaffected by other amino acids. Supplementation of amino acid-starved cells with substrates of system A causes a decrease in both ATA2 mRNA and system A transport activity. These results suggest a direct relationship between ATA2 expression and system A transport activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Transport Systems
  • Blotting, Northern
  • Carrier Proteins / biosynthesis*
  • Cell Line
  • Culture Media / metabolism
  • Fibroblasts / metabolism
  • Humans
  • Proline / metabolism
  • Protein Transport
  • RNA, Messenger / metabolism
  • Time Factors


  • Amino Acid Transport Systems
  • Carrier Proteins
  • Culture Media
  • RNA, Messenger
  • Proline