Two kinds of Hutchinson's sign, benign and malignant

J Am Acad Dermatol. 2001 Feb;44(2):305-7. doi: 10.1067/mjd.2001.112398.


We examined 6 subungual melanomas in situ and 18 melanocytic nevi and compared pigmentation of the nail plates and hyponychium with the use of a dermatoscope. Hutchinson's sign on the hyponychium was not always evidence of subungual melanoma because it can be seen in both diseases. However, there was a wide difference in their dermatoscopic features. We believe that observation of pigmentation on the hyponychium with the use of a dermatoscope contributes to the precise diagnosis of subungual melanoma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Humans
  • Melanoma / diagnosis*
  • Melanoma / pathology
  • Middle Aged
  • Nail Diseases / diagnosis*
  • Nail Diseases / pathology
  • Nails / pathology*
  • Nevus, Pigmented / diagnosis*
  • Nevus, Pigmented / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology