Regulation of Ets function by protein - protein interactions

Oncogene. 2000 Dec 18;19(55):6514-23. doi: 10.1038/sj.onc.1204035.

Abstract

Ets proteins are a family of transcription factors that share an 85 amino acid conserved DNA binding domain, the ETS domain. Over 25 mammalian Ets family members control important biological processes, including cellular proliferation, differentiation, lymphocyte development and activation, transformation and apoptosis by recognizing the GGA core motif in the promoter or enhancer of their target genes. Protein - protein interactions regulates DNA binding, subcellular localization, target gene selection and transcriptional activity of Ets proteins. Combinatorial control is a characteristic property of Ets family members, involving interaction between Ets and other key transcriptional factors such as AP-1, NFkappaB and Pax family members. Specific domains of Ets proteins interact with many protein motifs such as bHLH, bZipper and Paired domain. Such interactions coordinate cellular processes in response to diverse signals including cytokines, growth factors, antigen and cellular stresses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Binding Sites
  • Consensus Sequence
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • DNA-Binding Proteins / physiology*
  • Dimerization
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / physiology*
  • Humans
  • Macromolecular Substances
  • Mammals / genetics
  • Models, Genetic
  • Multigene Family*
  • NF-kappa B / metabolism
  • Nuclear Proteins / physiology
  • Protein Binding / physiology*
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-ets
  • Retinoblastoma Protein / physiology
  • Trans-Activators / physiology
  • Transcription Factor AP-1 / metabolism
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription Factors / physiology*
  • Transcription, Genetic / genetics
  • Transcription, Genetic / physiology

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA-Binding Proteins
  • Macromolecular Substances
  • NF-kappa B
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-ets
  • Retinoblastoma Protein
  • Trans-Activators
  • Transcription Factor AP-1
  • Transcription Factors
  • DNA