Ets target genes: past, present and future

Oncogene. 2000 Dec 18;19(55):6533-48. doi: 10.1038/sj.onc.1204034.

Abstract

Ets is a family of transcription factors present in species ranging from sponges to human. All family members contain an approximately 85 amino acid DNA binding domain, designated the Ets domain. Ets proteins bind to specific purine-rich DNA sequences with a core motif of GGAA/T, and transcriptionally regulate a number of viral and cellular genes. Thus, Ets proteins are an important family of transcription factors that control the expression of genes that are critical for several biological processes, including cellular proliferation, differentiation, development, transformation, and apoptosis. Here, we tabulate genes that are regulated by Ets factors and describe past, present and future strategies for the identification and validation of Ets target genes. Through definition of authentic target genes, we will begin to understand the mechanisms by which Ets factors control normal and abnormal cellular processes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Viral / genetics
  • Chromatin / genetics
  • DNA / metabolism
  • Embryonic and Fetal Development / genetics
  • Forecasting
  • Gene Expression Profiling
  • Gene Expression Regulation*
  • Genes*
  • Genes, Viral
  • Genetic Techniques
  • Hematopoiesis / genetics
  • Humans
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Multigene Family*
  • Oncogenes
  • Precipitin Tests
  • Promoter Regions, Genetic
  • Protein Binding
  • Proteins / classification
  • Proteins / genetics
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transcription, Genetic*

Substances

  • Chromatin
  • Proteins
  • Transcription Factors
  • DNA