Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons

Nat Neurosci. 2001 Feb;4(2):137-42. doi: 10.1038/83960.


Embryonic sensory and motoneurons depend on neurotrophic factors for survival. Here we show that their survival requires B-Raf, which, in this function, cannot be substituted by C-Raf. Sensory and motoneurons from b-raf-deficient mice do not respond to neurotrophic factors for their survival. However, these primary neurons can be rescued by transfection of a b-raf expression plasmid. In contrast, c-raf-deficient neurons survive in response to neurotrophic factors, similarly to neurons from wild-type mice. This points to an essential and specific function of B-Raf in mediating survival of sensory and motoneurons during development.

MeSH terms

  • Animals
  • Cell Survival / physiology
  • Cells, Cultured
  • Embryo, Mammalian / physiology
  • Embryonic and Fetal Development / physiology
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / embryology*
  • Mice
  • Motor Neurons / physiology*
  • Neurons, Afferent / physiology*
  • Proto-Oncogene Proteins c-raf / physiology*
  • Spinal Cord / cytology
  • Spinal Cord / embryology*


  • Proto-Oncogene Proteins c-raf