Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study

Arch Ophthalmol. 2001 Feb;119(2):191-6.


Objective: To determine whether 3 months of topical latanoprost treatment caused proliferative or degenerative effects on the peripheral iris of patients with glaucoma.

Methods: Seventeen patients requiring filtering surgery for primary open-angle glaucoma or pseudoexfoliation glaucoma were randomized to receive topical latanoprost for 3 months (n = 8) or alternative medication (n = 9) before surgery. A trabeculectomy and a peripheral iridectomy specimen was obtained from each patient during surgery. The tissue was subjected to histological and immunohistochemical evaluation using 2 cell cycle markers: proliferating cell nuclear antigen and nuclear-associated protein (Ki-67).

Results: No degenerative or pathological changes were seen in the latanoprost-treated irides, including the one specimen in this series in which there was an eye color change. Proliferating cell nuclear antigen and nuclear-associated protein markers were negative for changes in all the test specimens.

Conclusion: Short-term treatment with latanoprost does not produce morphological changes or cellular proliferation changes in the iris.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / therapeutic use*
  • Biomarkers
  • Exfoliation Syndrome / complications
  • Female
  • Glaucoma, Open-Angle / drug therapy*
  • Glaucoma, Open-Angle / etiology
  • Glaucoma, Open-Angle / pathology
  • Humans
  • Immunoenzyme Techniques
  • Intraocular Pressure / drug effects*
  • Iris / drug effects*
  • Iris / metabolism
  • Iris / pathology
  • Iris / surgery
  • Ki-67 Antigen / metabolism
  • Latanoprost
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Proliferating Cell Nuclear Antigen / metabolism
  • Prostaglandins F, Synthetic / therapeutic use*
  • Single-Blind Method
  • Trabeculectomy


  • Antihypertensive Agents
  • Biomarkers
  • Ki-67 Antigen
  • Ophthalmic Solutions
  • Proliferating Cell Nuclear Antigen
  • Prostaglandins F, Synthetic
  • Latanoprost