Antiamnesic effect of acyl-prolyl-containing dipeptide (GVS-111) in compression-induced damage to frontal cortex

Bull Exp Biol Med. 2000 Sep;130(9):846-8.


Antiamnestic effect of acyl-prolyl-containing dipeptide GVS-111 was demonstrated in rats with bilateral compression-induced damage to the frontal cortex. Both intraperitoneal and oral administration of the dipeptide improved retrieval of passive avoidance responses in rats with compression-induced cerebral ischemia compared to untreated controls.

MeSH terms

  • Animals
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / pathology
  • Cerebral Cortex / blood supply*
  • Cerebral Cortex / pathology*
  • Dipeptides / pharmacology*
  • Dipeptides / therapeutic use
  • Male
  • Nootropic Agents / pharmacology*
  • Nootropic Agents / therapeutic use
  • Rats


  • Dipeptides
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly