Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress

Bull Exp Biol Med. 2000 Oct;130(10):969-72.

Abstract

Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Amino-5-phosphonovalerate / pharmacology
  • Animals
  • Brain Ischemia / drug therapy
  • Brain Ischemia / metabolism
  • Cells, Cultured
  • Cerebellum / cytology
  • Cerebellum / drug effects
  • Cerebellum / metabolism
  • Dipeptides / pharmacology*
  • Glucose / deficiency
  • Glutamic Acid / metabolism
  • Glutamic Acid / toxicity*
  • Neurons / drug effects
  • Neurons / metabolism
  • Neuroprotective Agents / pharmacology*
  • Nootropic Agents / pharmacology*
  • Oxidative Stress*
  • Oxygen / metabolism
  • Piracetam / pharmacology
  • Rats
  • Rats, Wistar

Substances

  • Dipeptides
  • Neuroprotective Agents
  • Nootropic Agents
  • Glutamic Acid
  • ethyl phenylacetyl-Pro-Gly
  • 2-Amino-5-phosphonovalerate
  • Glucose
  • Oxygen
  • Piracetam