Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA

Arthritis Res. 2001;3(1):48-53. doi: 10.1186/ar139. Epub 2000 Oct 27.

Abstract

Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Animals
  • Arthritis, Experimental / immunology*
  • Arthritis, Experimental / microbiology
  • Arthritis, Experimental / pathology
  • Cell-Free System / immunology
  • Cells, Cultured
  • CpG Islands / immunology
  • Cytokines / biosynthesis*
  • Cytokines / immunology
  • Cytokines / metabolism
  • DNA, Bacterial / immunology*
  • Inflammation / immunology
  • Interleukin-12 / biosynthesis
  • Interleukin-12 / deficiency
  • Interleukin-12 / genetics
  • Interleukin-12 / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oligodeoxyribonucleotides / administration & dosage
  • Oligodeoxyribonucleotides / immunology*
  • RNA, Messenger / biosynthesis*
  • RNA, Messenger / immunology
  • Synovial Membrane / immunology*
  • Synovial Membrane / metabolism
  • Synovial Membrane / pathology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Adjuvants, Immunologic
  • CPG-oligonucleotide
  • Cytokines
  • DNA, Bacterial
  • Oligodeoxyribonucleotides
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • Interleukin-12