The function and regulation of vasa-like genes in germ-cell development

Genome Biol. 2000;1(3):REVIEWS1017. doi: 10.1186/gb-2000-1-3-reviews1017. Epub 2000 Sep 1.


The vasa gene, essential for germ-cell development, was originally identified in Drosophila, and has since been found in other invertebrates and vertebrates. Analysis of these vasa homologs has revealed a highly conserved role for Vasa protein among different organisms, as well as some important differences in its regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DEAD-box RNA Helicases
  • Gene Expression Regulation, Enzymologic
  • Germ Cells / cytology
  • Germ Cells / metabolism*
  • Humans
  • Invertebrates / embryology
  • Invertebrates / genetics
  • Protein Transport
  • RNA Helicases / genetics*
  • RNA Helicases / metabolism*
  • Sequence Homology
  • Vertebrates / embryology
  • Vertebrates / genetics


  • DDX4 protein, human
  • DEAD-box RNA Helicases
  • RNA Helicases