Abstract
The extensive polymorphism revealed in non-coding gene-regulatory sequences, particularly in the immune system, suggests that this type of genetic variation is functionally and evolutionarily far more important than has been suspected, and provides a lead to new therapeutic strategies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Gene Expression Regulation
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Genetic Predisposition to Disease / genetics
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Genetic Variation
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Humans
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Major Histocompatibility Complex / genetics
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Polymorphism, Genetic*
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Regulatory Sequences, Nucleic Acid / genetics*