Fenbendazole treatment without environmental decontamination eradicates Syphacia muris from all rats in a large, complex research institution

Contemp Top Lab Anim Sci. 2000 May;39(3):9-12.

Abstract

Syphacia muris parasitism was eliminated from rats and voles by feeding fenbendazole-medicated chow (150 ppm) for five 7-day periods; treatment periods were separated by 7-day periods of feeding non-medicated chow, yielding atotal treatment course of 9 weeks. No other manipulations to facilitate eradication, including the use of filter tops, autoclaved cages, environmental decontamination, colony depopulation, breeding cessation, and research restriction, were done. The examination of 3143 cellophane-tape impressions of the anus and 160 cecal examinations from euthanized rats and voles during the treatment period and for 7 months afterwards confirmed the efficacy of treatment. Treatment was rapidly effective in voles. In rats, pinworm eggs persisted at high levels for 2 weeks after the start of treatment, but no eggs were found after 22 days.

MeSH terms

  • Anal Canal / parasitology
  • Animal Feed
  • Animals
  • Animals, Laboratory*
  • Antinematodal Agents / administration & dosage
  • Antinematodal Agents / therapeutic use*
  • Arvicolinae
  • Cricetinae
  • Decontamination
  • Enterobiasis / prevention & control
  • Enterobiasis / veterinary*
  • Enterobius* / isolation & purification
  • Fenbendazole / administration & dosage
  • Fenbendazole / therapeutic use*
  • Housing, Animal
  • Parasite Egg Count / veterinary
  • Rats
  • Rodent Diseases / parasitology
  • Rodent Diseases / prevention & control*

Substances

  • Antinematodal Agents
  • Fenbendazole