Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study

Br J Oral Maxillofac Surg. 2001 Feb;39(1):34-9. doi: 10.1054/bjom.2000.0459.

Abstract

Objective: To study the efficacy of coumarin/troxerutine for the protection of salivary glands and mucosa during irradiation.

Design: Prospective, randomized, placebo-controlled, double-blind trial.

Setting: University hospital, Germany.

Patients: 48 patients who had radiotherapy to the head and neck.

Main outcome measures: Salivary gland scintigraphy and acute side-effects of radiotherapy (Radiation Therapy Oncology Group (RTOG) score).

Results: 23 patients (11 experimental, 12 placebo) completed the study. The global efficacy measure combining scintigraphy and RTOG score favoured the experimental arm (P=0.07). The RTOG score showed significantly fewer acute side-effects of radiation in the experimental arm (P<0.05).

Conclusion: The results suggest that coumarin/troxerutine have a favourable effect in the treatment of radiogenic sialadenitis and mucositis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Coumarins / therapeutic use*
  • Cranial Irradiation / adverse effects*
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Hydroxyethylrutoside / analogs & derivatives*
  • Hydroxyethylrutoside / therapeutic use*
  • Male
  • Middle Aged
  • Mouth Mucosa / radiation effects
  • Prospective Studies
  • Radiation Injuries / prevention & control*
  • Radiation-Protective Agents / therapeutic use*
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Salivary Glands / diagnostic imaging
  • Sialadenitis / etiology
  • Sialadenitis / prevention & control*
  • Sodium Pertechnetate Tc 99m
  • Treatment Outcome
  • Xerostomia / etiology
  • Xerostomia / prevention & control

Substances

  • Coumarins
  • Drug Combinations
  • Hydroxyethylrutoside
  • Radiation-Protective Agents
  • Radiopharmaceuticals
  • Venalot
  • troxerutin
  • Sodium Pertechnetate Tc 99m