Hepatic stem cells: from bone marrow cells to hepatocytes

Biochem Biophys Res Commun. 2001 Feb 16;281(1):1-5. doi: 10.1006/bbrc.2001.4270.


Hematopoiesis and the hepatic environment are known to have a close relationship at the time of hepatic development and systemic diseases. Recently, transplanted cells isolated from bone marrow of rodents and humans have been shown to differentiate into oval cells, which are considered to be hepatic stem cells, and hepatocytes in the liver. Then, purified hematopoietic stem cells were shown to have the ability to replace original liver cells in mice with hereditary tyrosinemia. In this review the interactions between hepatic stem cells are summarized and a hypothesis of hepatic differentiation will be proposed.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow Cells / physiology*
  • Cell Differentiation
  • Cell Lineage
  • Hematopoietic Stem Cells / physiology*
  • Hepatocytes / physiology*
  • Humans
  • Liver / cytology
  • Liver / drug effects
  • Models, Biological
  • Rats