Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: a gene family including the gene for prolactin-inducible protein

Biochem Biophys Res Commun. 2001 Feb 16;281(1):94-100. doi: 10.1006/bbrc.2001.4311.


We cloned two new paralogous genes that encode proteins homologous to seminal vesicle autoantigen (SVA) in rodents. The open reading frame of one mouse gene encodes a polypeptide consisting of 151 amino acid residues which has 43% identity to SVA. RT-PCR analysis showed selective expression in the colon, and thus the protein was tentatively named "SVA-like protein in the colon (SLP-C)". The other mouse gene has an open reading frame encoding 144 amino acid residues with 46 and 65% identity to SVA and SLP-C, respectively. Expression of this gene was detected in the mammary, submaxillary, parotid, and lacrimal glands, and this protein was named "SLP in the mammary gland (SLP-M)". Orthologs of both genes were also found in rats. The three homologous genes coding for SVA, SLP-C, and SLP-M may have been generated by gene duplication with divergence of tissue expression in the course of evolution. They comprise a unique structurally-related gene family. Moreover, these genes share significant sequence homology with that of another secretory glycoprotein, prolactin-inducible protein.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / chemistry
  • Animals
  • Apoptosis
  • Aspartic Acid Endopeptidases
  • Autoantigens / chemistry
  • Autoantigens / genetics*
  • Base Sequence
  • Carrier Proteins / genetics*
  • Cloning, Molecular
  • Colon / metabolism
  • DNA, Complementary / metabolism
  • Female
  • Glycoproteins / chemistry
  • Glycoproteins / genetics*
  • Lacrimal Apparatus / metabolism
  • Liver / metabolism
  • Mammary Glands, Animal / metabolism
  • Mice
  • Multigene Family*
  • Open Reading Frames
  • Parotid Gland / metabolism
  • Peptides / chemistry
  • Phylogeny
  • Rats
  • Reverse Transcriptase Polymerase Chain Reaction
  • Seminal Vesicle Secretory Proteins*
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Submandibular Gland / metabolism
  • Tissue Distribution


  • Amino Acids
  • Autoantigens
  • Carrier Proteins
  • DNA, Complementary
  • Glycoproteins
  • Peptides
  • Seminal Vesicle Secretory Proteins
  • seminal vesicle autoantigen
  • Aspartic Acid Endopeptidases
  • Sval1 protein, mouse
  • Sval1 protein, rat
  • Sval2 protein, mouse
  • Sval2 protein, rat